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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4E
All Species:
35.76
Human Site:
T116
Identified Species:
49.17
UniProt:
P06730
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P06730
NP_001959.1
217
25097
T116
R
G
G
R
W
L
I
T
L
N
K
Q
Q
R
R
Chimpanzee
Pan troglodytes
XP_523824
217
24938
T116
R
G
G
R
W
L
I
T
L
N
K
Q
Q
R
R
Rhesus Macaque
Macaca mulatta
XP_001092045
253
28850
S152
R
G
G
R
W
L
V
S
L
A
K
Q
Q
R
H
Dog
Lupus familis
XP_544992
217
25075
T116
R
G
G
R
W
L
I
T
L
N
K
Q
Q
R
R
Cat
Felis silvestris
Mouse
Mus musculus
Q3UTA9
244
27967
S144
Q
G
G
R
W
L
L
S
I
D
K
Q
L
R
H
Rat
Rattus norvegicus
P63074
217
25035
T116
R
G
G
R
W
L
I
T
L
N
K
Q
Q
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514651
236
27161
L131
T
V
E
D
F
W
A
L
Y
N
H
I
Q
L
S
Chicken
Gallus gallus
XP_420655
217
25026
T116
R
G
G
R
W
L
I
T
L
T
K
Q
Q
R
R
Frog
Xenopus laevis
P48597
213
24616
T112
R
G
G
R
W
L
I
T
L
N
K
Q
Q
R
R
Zebra Danio
Brachydanio rerio
Q9DFS6
215
24831
T114
R
G
G
R
W
L
I
T
L
S
K
Q
Q
R
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48598
259
29205
I159
K
Q
G
G
R
W
V
I
T
L
N
K
S
S
K
Honey Bee
Apis mellifera
XP_624290
213
24784
N112
C
G
G
R
W
L
I
N
L
D
K
K
Q
R
N
Nematode Worm
Caenorhab. elegans
O61955
248
27791
V111
Q
G
G
R
W
L
V
V
V
D
K
Q
R
R
T
Sea Urchin
Strong. purpuratus
NP_001091928
225
25645
G124
D
G
G
R
W
L
I
G
F
D
R
K
S
K
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81481
218
24452
K121
P
I
C
A
N
G
G
K
W
T
I
S
C
G
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23252
235
26501
K138
P
I
C
A
N
G
G
K
W
T
M
T
F
P
K
Baker's Yeast
Sacchar. cerevisiae
P07260
213
24236
S116
N
A
K
G
G
K
W
S
F
Q
L
R
G
K
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
59.2
99.5
N.A.
53.2
98.1
N.A.
71.6
92.1
88.4
82.9
N.A.
43.6
54.8
41.1
53.7
Protein Similarity:
100
98.6
69.1
99.5
N.A.
69.2
98.6
N.A.
74.1
94
94
92.6
N.A.
56.3
68.6
58.8
73.7
P-Site Identity:
100
100
73.3
100
N.A.
53.3
100
N.A.
13.3
93.3
100
93.3
N.A.
6.6
66.6
53.3
40
P-Site Similarity:
100
100
86.6
100
N.A.
86.6
100
N.A.
20
93.3
100
100
N.A.
33.3
80
86.6
66.6
Percent
Protein Identity:
N.A.
42.2
N.A.
39.5
31.8
N.A.
Protein Similarity:
N.A.
56.8
N.A.
54
55.3
N.A.
P-Site Identity:
N.A.
6.6
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
6.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
6
0
12
0
0
6
0
0
6
0
0
0
0
0
% A
% Cys:
6
0
12
0
0
0
0
0
0
0
0
0
6
0
0
% C
% Asp:
6
0
0
6
0
0
0
0
0
24
0
0
0
0
0
% D
% Glu:
0
0
6
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
6
0
0
0
12
0
0
0
6
0
0
% F
% Gly:
0
71
77
12
6
12
12
6
0
0
0
0
6
6
6
% G
% His:
0
0
0
0
0
0
0
0
0
0
6
0
0
0
12
% H
% Ile:
0
12
0
0
0
0
53
6
6
0
6
6
0
0
0
% I
% Lys:
6
0
6
0
0
6
0
12
0
0
65
18
0
12
12
% K
% Leu:
0
0
0
0
0
71
6
6
53
6
6
0
6
6
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
6
0
0
0
0
% M
% Asn:
6
0
0
0
12
0
0
6
0
36
6
0
0
0
6
% N
% Pro:
12
0
0
0
0
0
0
0
0
0
0
0
0
6
6
% P
% Gln:
12
6
0
0
0
0
0
0
0
6
0
59
59
0
0
% Q
% Arg:
48
0
0
71
6
0
0
0
0
0
6
6
6
65
48
% R
% Ser:
0
0
0
0
0
0
0
18
0
6
0
6
12
6
6
% S
% Thr:
6
0
0
0
0
0
0
42
6
18
0
6
0
0
6
% T
% Val:
0
6
0
0
0
0
18
6
6
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
71
12
6
0
12
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
6
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _